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ea0070aep37 | Adrenal and Cardiovascular Endocrinology | ECE2020

Physiologically based pharmacokinetic modelling to inform dosing in adrenal insufficiency and congenital adrenal hyperplasia

Whitaker Martin J , Bonner Jennifer J , Burt Howard , Johnson Trevor N , Porter John , Ross Richard JM

Background: Replacing physiological cortisol levels is important for the long-term health of patients with adrenal insufficiency and congenital adrenal hyperplasia (CAH). Modified-release formulations of hydrocortisone are one strategy being used to replace the cortisol circadian rhythm in adult patients but there is no data in children. Physiologically based pharmacokinetic (PBPK) modelling is a valuable tool for paediatric drug development1; however, there are no ...

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ea0065ja5 | Society for Endocrinology Journal Award – Clinical Endocrinology | SFEBES2019

Absorption and tolerability of taste-masked hydrocortisone granules in neonates, infants and children under 6 years of age with adrenal insufficiency

Neumann Uta , Whitaker Martin J , Wiegand Susanna , Krude Heiko , Porter John , Davies Madhu , Digweed Dena , Voet Bernard , Ross Richard J , Blankenstein Oliver

Clinical Endocrinology, 2018, 88(1): 2129 (DOI: https://doi.org/10.1111/cen.13447)...

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Endocrine Abstracts

Physiologically based pharmacokinetic modelling to inform dosing in adrenal insufficiency and congenital adrenal hyperplasia

Absorption and tolerability of taste-masked hydrocortisone granules in neonates, infants and children under 6 years of age with adrenal insufficiency

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